Collierville is centrally located in the Mid-South region of the United States in West Tennessee. Located on the eastern edge of Shelby County, Collierville is in the southeast growth corridor of Memphis, one of the most thriving metro areas in the South.

The community is easily accessible from State Highways 57 and 385 and U.S. Highway 72, and is only a few minutes south of Interstate 40 via State Highway 205. Interstate 55 is 25 miles to the west via State Highway 57 or U.S. 72.

Collierville is 137 miles east of Little Rock, AR; 200 miles west of Nashville; 300 miles south of St. Louis, MO; and 180 miles north of Jackson, MS. The city is within 23 miles of the Port of Memphis, the second largest inland port on the Mississippi River; and it is within 15 miles of the Memphis International Airport.

Collierville is in the Central Time Zone.